Regulation by S-Nitrosylation of Protein Post-translational Modification
نویسندگان
چکیده
منابع مشابه
Evidence against Stable Protein S-Nitrosylation as a Widespread Mechanism of Post-translational Regulation
S-nitrosation, commonly referred to as S-nitrosylation, is widely regarded as a ubiquitous, stable post-translational modification that directly regulates many proteins. Such a widespread role would appear to be incompatible with the inherent lability of the S-nitroso bond, especially its propensity to rapidly react with thiols to generate disulfide bonds. As anticipated, we observed robust and...
متن کاملS-nitrosylation: an emerging redox-based post-translational modification in plants.
S-nitrosylation, the covalent attachment of a nitric oxide moiety to a cysteine thiol, is now established as a key post-translational modification in animals. This process has been shown to regulate the function of a wide variety of regulatory, structural, and metabolic proteins. The emerging evidence now suggests that S-nitrosylation may also have a central function in plant biology.
متن کاملAssembly of tubulin by classic myelin basic protein isoforms and regulation by post-translational modification.
Myelin basic protein (MBP), a highly cationic protein that maintains the structure of the myelin sheath, associates with tubulin in vivo. The in vitro assembly of tubulin by MBP was examined here using several assays. The unmodified C1 component of 18.5 kDa bovine MBP (bC1) assembled tubulin into microtubules in a dose-dependent manner via filamentous intermediates, and was able simultaneously ...
متن کاملPost-translational S-nitrosylation is an endogenous factor fine tuning the properties of human S100A1 protein.
BACKGROUND S100A1 protein is a proposed target of molecule-guided therapy for heart failure. RESULTS S-Nitrosylation of S100A1 is present in cells, increases Ca(2+) binding, and tunes the overall protein conformation. CONCLUSION Thiol-aromatic molecular switch is responsible for NO-related modification of S100A1 properties. SIGNIFICANCE Post-translational S-nitrosylation may provide funct...
متن کاملPost-translational modification by SUMO.
Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2012
ISSN: 0021-9258
DOI: 10.1074/jbc.r111.285742